A potent GSK3 inhibitor
Catalog #: 2595 | abID: ab146582

Product Details

abID ab146582
Alternate Name 6-N-[2-[[4-(2,4-dichlorophenyl)-5-imidazol-1-ylpyrimidin-2-yl]amino]ethyl]-3-nitropyridine-2,6-diamine; CT 98014
Appearance Crystalline solid
CAS # 556813-39-9
Molecular Formula C₂₀H₁₇Cl₂N₉O₂
Molecular Weight 486.31
Purity >98% by HPLC
Solubility DMSO (~ 4 mg/ml)
SMILES C1=CC(=C(C=C1Cl)Cl)C2=NC(=NC=C2N3C=CN=C3)NCCNC4=NC(=C(C=C4)[N+](=O)[O-])N
InChi InChI=1S/C20H17Cl2N9O2/c21-12-1-2-13(14(22)9-12)18-16(30-8-7-24-11-30)10-27-20(29-18)26-6-5-25-17-4-3-15(31(32)33)19(23)28-17/h1-4,7-11H,5-6H2,(H3,23,25,28)(H,26,27,29)
PubChem CID 53396311
Handling Protect from air and light
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. CHIR-98014 is a potent, selective and ATP-competitive inhibitor of GSK3α and GSK3β (IC₅₀ = 0.65 and 0.58 nM, respectively). In addition, CHIR-98014 displays 500 to greater than 1000-fold selectivity towards GSK3 than other protein kinases such as cdc2 and ERK2. CHIR98014 also reduces tau phosphorylation in rat brains and supports Wnt signaling during osteogenesis.

Why buy BioVision Products?
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.