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A potent histone deacetylase inhibitor
Catalog #: 2261
SKU-Size Size Price Qty
2261-1 1 mg
2261-5 5 mg
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Product Details

Alternate Name N-​(2-​amino-​5-​fluorophenyl)-​4-​[[[1-​oxo-​3-​(3-​pyridinyl)-​2-​propen-​1-​yl]amino]methyl]-​benzamide
Peptide Sequence No
Appearance White to off-white solid
CAS # 743420-02-2
Molecular Formula C₂₂H₁₉FN₄O₂
Molecular Weight 390.41
Purity ≥98%
Solubility DMSO
InChi InChI=1S/C22H19FN4O2/c23-18-8-9-19(24)20(12-18)27-22(29)17-6-3-16(4-7-17)14-26-21(28)10-5-15-2-1-11-25-13-15/h1-13H,14,24H2,(H,26,28)(H,27,29)
PubChem CID 53394037
Handling Protect from light and mositure
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. A new benzamide class of histone deacetylase (HDAC) inhibitor with marked anti-tumor activity. It increases histone H3 acetylation levels in LoVo and HT29 colon cancer cells at concentrations as low as 4 µM. Additionally, chidamide affects the activation of oncogenic signaling kinases by dose-dependently reducing phosphorylated Akt, mTOR, p70S6k, Raf, and Erk1/2 protein expression in colon cancer cells.

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