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Chelerythrine chloride

A selective protein kinase C (PKC) inhibitor
Catalog #: 2064

Product Details

Cat # +Size 2064-5
Size 5 mg
Alternate Name 1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium chloride
Appearance Yellow to orange solid
CAS # 3895-92-9
Molecular Formula C₂₁H₁₈NO₄Cl
Molecular Weight 383.82
Purity ≥98% by HPLC
Solubility DMSO (> 10 mg/ml) or H₂O (5 mg/ml)
SMILES C[N+]1=C2C(=C3C=CC(=C(C3=C1)OC)OC)C=CC4=CC5=C(C=C42)OCO5.[Cl-]
InChi InChI=1S/C21H18NO4.ClH/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22;/h4-10H,11H2,1-3H3;1H/q+1;/p-1
PubChem CID 72311
MDL Number MFCD00060717
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. A selective protein kinase C (PKC) inhibitor (IC₅₀ =0.66 µM). Chelerythrine is at least 100-fold more selective for PKCs than for other kinases. It induces apoptotic cell death in polymorphonuclear leukocyte through activation of caspase-3. In addition, Chelerythrine treated cells underwent apoptosis, with features that suggest involvement of the mitochondrial pathway, and through a mechanism that involves inhibition of the anti-apoptotic inhibitor BclXL.

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