Product Details
| Cat # +Size | 6859-25 |
|---|---|
| Size | 25 μg |
| Antibody Target | Chd1 |
| Alternate Name | CHD-1, ATPase DNA-binding protein 1 |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | Polyclonal antibody raised in rabbit against human CHD1 (Chromodomain helicase DNA binding protein 1), using a GST fused recombinant protein. |
| Accession # | O14646 |
| Gene ID | 1105 |
| Appearance | Colorless liquid |
| Formulation | In PBS with 0.05% sodium azide and 0.05% ProClin 300. |
| Purification | Protein G purified |
| Species Reactivity | Human. |
| Application | Western blot |
| Positive Control | Western blot: HeLa cells |
| Application & Usage | Western Blot: 1:500 |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
CHD1 is a member of the CHD (chromodomain-helicase-DNA-binding) family of proteins that interacts with nucleosomes and plays a role in chromatin remodeling to modulate transcription. The members of the CHD family of proteins possess 3 common structural and functional domains: a chromodomain (chromatin organization modifier), an SNF2-like helicase/ATPase domain, and a C-terminal DNA-binding domain. CHD1 has been shown to interact with the transcriptional corepressor NCoR and histone deacetylase 1 indicating a role in transcriptional regulation. CHD1 has also been shown to interact with the Paf1 complex and Rtf1 implicating an additional role in transcriptional elongation.
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