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Chaetocin

A selective histone lysine methyltransferase (HKMT) inhibitor
Catalog #: 2283
$175.00

Product Details

Cat # +Size 2283-500
Size 500 µg
Alternate Name (3S,3'S,5aR,5aR,10bR,10'bR,11aS,11'aS)­-2,2',3,3',5a,5'a,6,6'-octahydro-3,3'-bis(hydroxymethyl­)-2,2'-dimethyl-[10b,10'b(11H,11'H)-bi3,11a-epidithio­-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4­,4'-tetrone
Appearance Off-white solid
CAS # 28097-03-2
Molecular Formula C₃₀H₂₈N₆O₆S₄
Molecular Weight 696.84
Purity ≥95%
Solubility DMSO (~7 mg/ml)
SMILES CN1C(=O)C23CC4(C(N2C(=O)C1(SS3)CO)NC5=CC=CC=C54)C67CC89C(=O)N(C(C(=O)N8C6NC1=CC=CC=C71)(SS9)CO)C
InChi InChI=1S/C30H28N6O6S4/c1-33-21(39)27-11-25(15-7-3-5-9-17(15)31-19(25)35(27)23(41)29(33,13-37)45-43-27)26-12-28-22(40)34(2)30(14-38,46-44-28)24(42)36(28)20(26)32-18-10-6-4-8-16(18)26/h3-10,19-20,31-32,37-38H,11-14H2,1-2H3
InChi Key PZPPOCZWRGNKIR-UHFFFAOYSA-N
PubChem CID 161591
MDL Number MFCD00133163
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A fungal mycotoxin that inhibits the histone lysine methyltransferase (HKMT) SU(VAR)3-9 (IC₅₀ = 0.8 μM). Inhibits other Lys9-specific HMTs, including G9a (IC₅₀ = 2.5 μM) and DIM5 (IC₅₀ = 3 μM). Selectivity for Lys9-HMTs is indicated by higher IC₅₀ values (>90 μM) for Lys20-specific PRSET7, Lys27-specific EZH2, and Lys4-specific SET7/9.


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