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CH7057288

A selective tropomyosin receptor kinase (TRK) inhibitor
Catalog #: B2514
SKU-Size Size Price Qty
B2514-5 5 mg
$165.00
B2514-25 25 mg
$650.00
More Sizes Get Quote

Product Details

Alternate Name CH-7057288; N-(tert-butyl)-2-((6,6-dimethyl-8-(methylsulfonamido)-11-oxo-6,11-dihydronaphtho[2,3-b]benzofuran-3-yl)ethynyl)-6-methylisonicotinamide
Appearance Crystalline solid
CAS # 2095616-82-1
Molecular Formula C₃₂H₃₁N₃O₅S
Molecular Weight 569.68
Purity ≥98% by HPLC
Solubility >30 mg/ml in DMSO
SMILES CC1=NC(=CC(=C1)C(=O)NC(C)(C)C)C#CC2=CC3=C(C=C2)C4=C(O3)C(C5=C(C4=O)C=CC(=C5)NS(=O)(=O)C)(C)C
InChi InChI=1S/C32H31N3O5S/c1-18-14-20(30(37)34-31(2,3)4)16-21(33-18)10-8-19-9-12-24-26(15-19)40-29-27(24)28(36)23-13-11-22(35-41(7,38)39) 17-25(23)32(29,5)6/h9,11-17,35H,1-7H3,(H,34,37)
InChi Key DCGOHGQJHJXBGW-UHFFFAOYSA-N
PubChem CID 131839646
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CH7057288 as a potent and selective TRK (tropomyosin receptor kinase) inhibitor that may be useful in inhibiting TRK fusion-positive cancer cell growth. CH7057288 shows selective inhibitory activity against TRKA, TRKB, and TRKC in cell-free kinase assays and suppresses proliferation of TRK fusion–positive cell lines, but not that of TRK-negative cell lines.


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