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Product Details
| Antibody Target | cGMP |
|---|---|
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | 2'O-succinyl guanosine-3',5' cyclic monophosphate |
| Appearance | Colorless liquid |
| Formulation | In phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% thimerosal |
| Purification | Affinity purified |
| Species Reactivity | All species |
| Application | ELISA |
| Application & Usage | 1:10-50 dilutions for nonradioactive EIA assays (10 µl/assay in an 70 µl assay reaction). The material is sufficient for performing 100-500 nonradioactive EIA assays or 6,000 radioactive assays. Detect 0.1-10 pmol/assay in a 70 µl assay reaction using non |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Cyclic guanosine monophosphate (cGMP) serves as a second messenger in a manner similar to that observed with cAMP. Peptide hormones, such as the natriuretic factors, activate receptors that are associated with membrane-bound guanylate cyclase (GC). Receptor activation of GC leads to the conversion of GTP to cGMP. Nitric oxide (NO) also stimulates cGMP production by activating soluble GC, perhaps by binding to the heme moiety of the enzyme. Similar to cAMP, cGMP mediates most of its intracellular effects through the activation of specific cGMP dependent protein kinases (PKG).
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