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cGAMP disodium salt

A potent STING ligand
Catalog #: 2435
$135.00

Product Details

Cat # +Size 2435-100
Size 100 µg
Alternate Name Cyclic (Adenosine Monophosphate-Guanosine Monophosphate); cyclic GMP-AMP; c-(GpAp)
Appearance Crystalline solid
CAS # 849214-04-6 (free acid)
Molecular Formula C₂₀H₂₂N₁₀O₁₃P₂ . 2Na
Molecular Weight 718.37
Purity ≥98% by HPLC
Solubility Water
SMILES C1C2C(C(C(O2)N3C=NC4=C3NC(=NC4=O)N)OP(=O)(OCC5C(C(C(O5)N6C=NC7=C6N=CN=C7N)O)OP(=O)(O1)O)O)O
InChi InChI=1S/C20H24N10O13P2/c21-14-8-15(24-3-23-14)29(4-25-8)18-11(32)12-7(41-18)2-39-45(36,37)43-13-10(31)6(1-38-44(34,35)42-12)40-19(13)30-5-26-9-16(30)27-20(22)28-17(9)33/h3-7,10-13,18-19,31-32H,1-2H2,(H,34,35)(H,36,37)(H2,21,23,24)(H3,22,27,28,33)/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s1
InChi Key XRILCFTWUCUKJR-INFSMZHSSA-N
PubChem CID 71563406
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A potent STING ligand. Second messenger in human and mouse cells that triggers interferon production in response to cytosolic DNA. Binding to STING leads to activation of IRF3 (IFN regulatory factor 3) and the induction of interferon-β. Plays a role in bacterial chemotaxis and colonization.


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