CFTR Inhibitor, GlyH-101

A Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor
Catalog #: 2863 | abID:

Product Details

Alternate Name 2-​[(3,​5-​dibromo-​2,​4-​dihydroxyphenyl)methylene]hydrazide N-​2-​naphthalenyl-​glycine; GlyH-101; Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor II
Appearance Yellow solid
CAS # 328541-79-3
Molecular Formula C₁₉H₁₅Br₂N₃O₃
Molecular Weight 493.15
Purity ≥98%
Solubility DMSO (>100 mg/ml)
InChi InChI=1S/C19H15Br2N3O3/c20-15-8-13(18(26)17(21)19(15)27)9-23-24-16(25)10-22-14-6-5-11-3-1-2-4-12(11)7-14/h1-9,22-23,27H,10H2,(H,24,25)/b13-9-
PubChem CID 11260414
MDL Number MFCD01532954
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


CFTR Inhibitor II, or GlyH-101, is a glycine hydrazide that selectively and reversibly blocks the CFTR channel (Ki = 4.3 µM). GlyH-101 binds to a site at the external pore of CFTR, occluding the pore and rapidly preventing chloride transport.

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