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Cetirizine dihydrochloride

A selective histamine H1 receptor antagonist
Catalog #: B2993
SKU-Size Size Price Qty
B2993-100 100 mg
$60.00
B2993-500 500 mg
$235.00
More Sizes Get Quote

Product Details

Alternate Name 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid,dihydrochloride; (+/-)-(2-(4-(p-Chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)acetic acid, dihydrochloride; UCB-P 071; Zyrtec; Reactine
Appearance White Powder
CAS # 83881-52-1
Molecular Formula C₂₁H₂₇Cl₃N₂O₃
Molecular Weight 461.81
Purity >98.0%
Solubility ~10 mg/ml in PBS, pH 7.2, ~12 mg/ml in DMSO, ~3 mg/ml in DMF
SMILES C1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl.Cl.Cl
InChi InChI=1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H
InChi Key PGLIUCLTXOYQMV-UHFFFAOYSA-N
PubChem CID 55182
MDL Number MFCD00941428
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

Cetirizine is a selective histamine H1 receptor antagonist with a Ki of 6 nM. It is a highly efficacious, well-tolerated, treatment for the management of Allergic Rhinitis. Cetirizine exerts anti-inflammatory effects apart from H1 antagonism. It significantly decreases the amounts of leukotriene B4 generated from neutrophil granulocytes. It inhibits aerosol histamine-induced bronchospasm in guinea pigs (ED₅₀ value of 100 μg/kg, p.o.).


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