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Cerdulatinib

A novel, dual spleen tyrosine kinase (Syk) and janus kinase (JAK) inhibitor
Catalog #: 2803
SKU-Size Size Price Qty
2803-5 5 mg
$115.00
2803-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name 4-(cyclopropylamino)-2-((4-(4-(ethylsulfonyl)piperazin-1-yl)phenyl)amino)pyrimidine-5-carboxamide; PRT2070; PRT-2070; PRT 2070; PRT-062070; PRT 062070; PRT062070.
Appearance White solid
CAS # 1198300-79-6
Molecular Formula C₂₀H₂₇N₇O₃S
Molecular Weight 445.54
Purity ≥98% by HPLC
Solubility DMSO (>40 mg/ml)
SMILES CCS(=O)(=O)N1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4CC4)C(=O)N
InChi nChI=1S/C20H27N7O3S/c1-2-31(29,30)27-11-9-26(10-12-27)16-7-5-15(6-8-16)24-20-22-13-17(18(21)28)19(25-20)23-14-3-4-14/h5-8,13-14H,2-4,9-12H2,1H3,(H2,21,28)(H2,22,23,24,25)
InChi Key BGLPECHZZQDNCD-UHFFFAOYSA-N
PubChem CID 44595079
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cerdulatinib is a novel, dual spleen tyrosine kinase (Syk) and janus kinase (JAK) inhibitor. It preferentially inhibits JAK1 and JAK3 dependent cytokine mediated signaling and functional responses in various cell types. IL2 mediated STAT5 Y694 is inhibited with an IC₅₀ of 0.27 μM, while IL4 mediated signaling to STAT6 Y641 and functional responses in B cells and monocytes, namely CD69, CD25, and CD23 up-regulation, are inhibited with IC₅₀’s within the range of 0.11 μM to 0.57 μM.


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