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A highly selective JAK2 inhibitor
Catalog #: B2473
SKU-Size Size Price Qty
B2473-5 5 mg
B2473-25 25 mg
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Product Details

Alternate Name N-(3-(4-methylpiperazin-1-yl)phenyl)-8-(4-(methylsulfonyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; CEP33779
Appearance Yellow solid
CAS # 1257704-57-6
Molecular Formula C₂₄H₂₆N₆O₂S
Molecular Weight 462.57
Purity ≥98% by HPLC
Solubility ~50 mg/ml DMSO
InChi InChI=1S/C24H26N6O2S/c1-28-13-15-29(16-14-28)20-6-3-5-19(17-20)25-24-26-23-22(7-4-12-30(23)27-24) 18-8-10-21(11-9-18)33(2,31)32/h3-12,17H,13-16H2,1-2H3,(H,25,27)
PubChem CID 57336812
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


CEP-33779 is a potent and orally available inhibitor of JAK2 (IC₅₀ = 1.3 nM). It displays 65-fold selectivity for JAK2 over JAK3. CEP-33779 induces regression of established colorectal tumors, reduces angiogenesis, and reduces proliferation of tumor cells.

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