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CEP-32496

A specific and selective inhibitor of the activity of the mutated form (V600E) of B-raf kinase.
Catalog #: 9615
SKU-Size Size Price Qty
9615-5 5 mg
$145.00
9615-25 25 mg
$575.00
More Sizes Get Quote

Product Details

Alternate Name 1-(3-((6,7-dimethoxyquinazolin-4-yl)oxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea; AC013773
Appearance Crystalline solid
CAS # 1188910-76-0
Molecular Formula C₂₄H₂₂F₃N₅O₅
Molecular Weight 517.47
Purity ≥98% by HPLC
Solubility DMSO
SMILES CC(C)(C1=CC(=NO1)NC(=O)NC2=CC(=CC=C2)OC3=NC=NC4=CC(=C(C=C43)OC)OC)C(F)(F)F
InChi InChI=1S/C24H22F3N5O5/c1-23(2,24(25,26)27)19-11-20(32-37-19)31-22(33)30-13-6-5-7-14(8-13)36-21-15-9-17(34-3)18(35-4)10-16(15)28-12-29-21/h5-12H,1-4H3,(H2,30,31,32,33)
InChi Key DKNUPRMJNUQNHR-UHFFFAOYSA-N
PubChem CID 56846693
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CEP-32496 specific and selective inhibitor of the activity of the mutated form (V600E) of B-raf kinase. It inhibits the activation of the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway and may result in a decrease in the proliferation of tumor cells expressing the mutated B-raf gene.


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