Product Details
| Alternate Name | Celebrex, Celebra, Celecox, SC-58635 |
|---|---|
| Appearance | Off-white solid |
| CAS # | 169590-42-5 |
| Molecular Formula | C₁₇H₁₄F₃N₃O₂S |
| Molecular Weight | 381.37 |
| Purity | ≥99% |
| Solubility | DMSO (200 mg/ml) or EtOH (100 mg/ml) |
| SMILES | CC1=CC=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F |
| InChi | InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25) |
| InChi Key | RZEKVGVHFLEQIL-UHFFFAOYSA-N |
| PubChem CID | 2662 |
| MDL Number | MFCD00941298 |
| Handling | Protect from light and air |
| Storage Conditions | -20°C |
| Shipping Conditions | RT |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Celecoxib is a highly selective COX-2 inhibitor and primarily inhibits prostaglandin production. Celecoxib is approximately 7.6-fold more selective for COX-2 inhibition over COX-1. This specificity allows celecoxib to reduce inflammation and pain while minimizing gastrointestinal adverse drug reactions that are common with non-selective non-steroidal anti-inflammatory drugs.
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Mao et al., Melanoma-Educated CD14+ Cells Acquire a Myeloid-Derived Suppressor Cell Phenotype through COX-2–Dependent Mechanisms. Cancer Res., Jul 2013; 73: 3877 - 3887.
Natasa Obermajer et al., Induction and stability of human Th17 cells require endogenous NOS2 and cGMP-dependent NO signaling. J. Exp. Med., Jun 2013; 210: 1433 - 1445.
Natasa Obermajer, et. al. Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells. Blood, Nov 2011; 118: 5498 - 5505.
Fujita, M. et. al. COX-2 Blockade Suppresses Gliomagenesis by Inhibiting Myeloid-Derived Suppressor Cells. Cancer Res., Apr 2011; 71: 2664 - 2674.
Lee, H. et al. Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders PNAS, Feb 2010; 107: 2159 - 2164.
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