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Cdk9 Inhibitor II

A selective inhibitor of Cdk9
Catalog #: B2903
SKU-Size Size Price Qty
B2903-1 1 mg
$85.00
B2903-5 5 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name CAY10574; UNII-ZG0O47K626; ZG0O47K626; CAN508; 4-(3,5-Diamino-1H-pyrazol-4-ylazo)-phenol; 4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol; 3,5-diamino-4-(4-hydroxyphenyl)azopyrazole; 4-Arylazo-3,5-diamino-1H-pyrazole 31b
Appearance A crystalline solid
CAS # 140651-18-9
Molecular Formula C₉H₁₀N₆O
Molecular Weight 218.22
Purity ≥95%
Solubility ~0.5 mg/ml in DMSO and DMF
SMILES C1=CC(=CC=C1N=NC2=C(NN=C2N)N)O
InChi InChI=1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-1-3-6(16)4-2-5/h1-4,16H,(H5,10,11,14,15)
InChi Key AYZRKFOEZQBUEA-UHFFFAOYSA-N
PubChem CID 135398514
MDL Number MFCD09262258
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

Cdk9 Inhibitor II is a potent and selective inhibitor of Cdk9 with an IC₅₀ value of 0.35 µM in vitro. It is also an inhibitor of Cdk2-cyclin E with respect to ATP, with Ki and IC₅₀ values of 13.3 µM and 20 µM respectively. It reduces the frequency of S-phase cells in the cancer cell line HT-29 and decreases the phosphorylation of the retinoblastoma protein and the C-terminal domain of RNA polymerase II. It inhibits mRNA synthesis and induces the tumor suppressor protein p53. It inhibits cell proliferation of cancer cell lines such as MCF-7, HOS, G361, and K562 cells with IC₅₀ values of 33 µM, 49 µM, 64 µM, and 62 µM respectively.


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