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Cdk4 Inhibitor

A potent cyclin D1-CDK4 inhibitor
Catalog #: B2928
SKU-Size Size Price Qty
B2928-5 5 mg
$145.00
B2928-25 25 mg
$575.00
More Sizes Get Quote

Product Details

Alternate Name 2-Bromo-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione; K00024; Cyclin-dependent kinase 4 Inhibitor
Appearance Solid
CAS # 546102-60-7
Molecular Formula C₂₀H₁₀BrN₃O₂
Molecular Weight 404.22
Purity 95%
Solubility ~30 mg/ml in DMSO and DMF
~0.25 mg/ml in Ethanol
SMILES C1=CC=C2C(=C1)C3=C4C(=C5C6=C(C=C(C=C6)Br)NC5=C3N2)C(=O)NC4=O
InChi InChI=1S/C20H10BrN3O2/c21-8-5-6-10-12(7-8)23-18-14(10)16-15(19(25)24-20(16)26)13-9-3-1-2-4-11(9)22-17(13)18/h1-7,22-23H,(H,24,25,26)
InChi Key NMFKDDRQSNVETB-UHFFFAOYSA-N
PubChem CID 5330797
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

Cdk4 Inhibitor is an indolocarbazole which is a potent, selective and ATP competitive cyclin D1/CDK4 inhibitor. It has an IC₅₀ value of 76 nM. It inhibits tumor cell growth, arrests tumor cells at the G1 phase, and inhibits pRb phosphorylation in HCT-116 and NCI-H460 cells with IC₅₀ < 3.0 µM.


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