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CD73/NT5E Antibody (CT)

Polyclonal Antibody to detect CD73 in human and mouse samples.
Catalog #: 6802
$245.00

Product Details

Cat # +Size 6802-100
Size 100 μl
Antibody Target CD73/NT5E
Alternate Name NT5E; NT5; NTE; 5'-nucleotidase; Ecto-5'-nucleotidase
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen This CD73 (NT5E) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 520-550 amino acids from the C-terminal region of human CD73 (NT5E).
Accession # P21589
Gene ID 4907
Appearance Colorless liquid
Formulation In PBS with 0.09% (W/V) sodium azide.
Purification Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Species Reactivity Human, Mouse.
Application Western blot, IHC.
Positive Control Western blot: mouse brain tissue lysate, NT5E 293 ceel lysate. IHC: human placenta tissue.
Application & Usage WB: 1:1000, IHC: 1:10 – 1:50.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CD73 (also designated ecto-5'-nucleotidase, E5NT, NT, NT5, NTE, eN and eNT) is a glycosyl-phosphatidylinositol (GPI)-anchored adhesion protein that catalyzes the dephosphorylation of extracellular purine and pyrimidine nucleotides to their corresponding bioactive nucleosides. CD73 is a dimer of two identical subunits that depends on GPI to link with the external face of the plasma membrane. Similar to other GPI-anchored proteins, CD73 mediates co-stimulatory signals in T cell activation. CD73 has few structural variants, yet elicits diverse biological function through differential regulation in endothelial cells (EC), subpopulations of B and T cells, germinal center follicular dendritic cells and on thymic medullary reticular fibroblasts. For example, IgG mediated neutralization of CD73 interferes with lymphocyte adhesion to EC, and blocks aggregation of germinal center B cells and follicular dendritic cells. Furthermore, IgG-mediated targeting of lymphocyte CD73, but not of endothelial cell CD73, causes shedding of CD73 and tyrosine phosphorylation of proteins.


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