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Product Details
| Cat # +Size | 7314-100 |
|---|---|
| Size | 100 μg |
| Alternate Name | Membrane cofactor protein isoform 14, AHUS2, MCP, MIC10, TLX, TRA2.10 |
| Gene Symbol | CD46 |
| Gene ID | 4179 |
| Accession # | P15529 |
| Source | E. coli |
| Appearance | Liquid |
| Physical Form Description | 1 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.1 M NaCl and 20% glycerol. |
| Molecular Weight | 33.8 kDa (302 aa, 35-313 aa + His tag), confirmed by MALDI-TOF. |
| Purity by SDS-PAGE | ≥85% |
| Endotoxin Level | < 1.0 EU per 1 microgram of protein |
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSCEEPPTF EAMELIGKPK PYYEIGERVD YKCKKGYFYI PPLATHTICD RNHTWLPVSD DACYRETCPY IRDPLNGQAV PANGTYEFGY QMHFICNEGY YLIGEEILYC ELKGSVAIWS GKPPICEKVL CTPPPKIKNG KHTFSEVEVF EYLDAVTYSC DPAPGPDPFS LIGESTIYCG DNSVWSRAAP ECKVVKCRFP VVENGKQISG FG |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -80°C |
| Shipping Conditions | Dry Ice |
| USAGE | For Research Use Only! Not to be used in humans |
Details
Membrane cofactor protein isoform 14, also known as CD46, is a type I membrane protein that has cofactor activity for inactivation of complement components C3b and C4b by serum factor I. This function resides in the complement control protein repeats (CCPs), with CCP1-4 essential for regulation. CD46 is widely distributed on thymocytes, T cells, B cells, monocytes, granulocytes, NK cells, platelets, endothelial cells, epithelial cells, fibroblasts, placenta and sperm, but not on erythrocyte. Recombinant human CD46 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
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