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CD45 FITC Monoclonal Antibody (Clone HI30)

Mouse monoclonal FITC conjugated antibody to detect CD45 in human samples.
Catalog #: 6958
SKU-Size Size Price Qty
6958-25 25 tests
$105.00
6958-100 100 tests
$245.00
More Sizes Get Quote

Product Details

Antibody Target CD45
Alternate Name CD45, CD 45, CD-45, CD45 antibody, CD45 monoclonal, CD45 monoclonal Ab, CD45 monoclonal antibody, CD45 mAb, CD 45 mAB, CD 45 monoclonal antibody, CD-45 monoclonal antibody, CD-45 mAB, CD-45 monoclonal antibody, CD45 FITC antibody, CD45 FITC monoclonal, CD45 FITC monoclonal Ab, CD45 FITC monoclonal antibody, CD45 FITC mAb, CD 45 FITC mAB, April-AB-15
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG1, Kappa
Immunogen Human CD45
Accession # P08575
Gene ID 5788
Appearance Colorless liquid
Formulation Phosphate-buffered aqueous solution pH 7.2, ≤0.09% Sodium azide, may contain carrier protein/stabilizer.
Purification Affinity chromatography.
Species Reactivity Human
Application Flow cytometry
Positive Control FACS: Human peripheral blood lymphocytes
Application & Usage Flow (Cell Surface): 5 µl/1x10^6 cells, Volume per test: 5 µl (0.25 µg).
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CD45, a transmembrane multifunctional glycoprotein, is a member of Type I receptor-linked PTPase family and is expressed as multiple isoforms due to alternative splicing. Expression of these isoforms is highly regulated and shift in this expression determines T-cell activation. CD45RB consists of exon B and is predominantly expressed in naïve T-cells secreting IL-2. Its expression is low in primed/memory T cells, cells that express Th2 cytokines such as IL-4 and IL-10 and population of T-cells with regulatory function. Immunotherapy with CD45RB antibody is being widely studied in transplantation and vaccination. CD45 antibodies are commonly used to identify tumors of lymphoid origin. The HI130 monoclonal antibody specifically reacts with the 180 kDa, 190 kDa, 205 kDa, and 220 kDa isoforms of the human leukocyte common antigen (LCA) CD45. It is expressed on lymphocytes, granulocytes, monocytes, thymocytes, and eosinophils, but not on mature erythrocytes, platelets, mature erythroid cells of bone marrow, and non-hematopoietic tissues. CD45 is essential for T cell activation and the tyrosine phosphatase activity of its intracellular region is integral for signal transduction.


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