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A selective RARgamma agonist and stem cell fate modulator
Catalog #: 2636
SKU-Size Size Price Qty
2636-5 5 mg
2636-25 25 mg
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Product Details

Alternate Name 6-​(4-​hydroxy-​3-​tricyclo[,​7]dec-​1-​ylphenyl)-​2-​naphthalenecarboxylic acid; AHPN
Appearance White solid
CAS # 125316-60-1
Molecular Formula C₂₇H₂₆O₃
Molecular Weight 398.49
Purity >95%
Solubility DMSO (>10 mg/ml)
SMILES C1C2CC3CC1CC(C2)(C3)C4=C(C=CC(=C4)C5=CC6=C(C=C5)C=C(C=C6)C(=O)O)O
InChi InChI=1S/C27H26O3/c28-25-6-5-22(20-1-2-21-11-23(26(29)30)4-3-19(21)10-20)12-24(25)27-13-16-7-17(14-27)9-18(8-16)15-27/h1-6,10-12,16-18,28H,7-9,13-15H2,(H,29,30)
PubChem CID 135411
MDL Number MFCD3106506
Handling Protect from air and light
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


CD437 is the adamantyl arotinoid of the retinoid-related molecule family that acts as a selective agonist of retinoic acid receptor (RAR)γ (Kds = 6.5 μM, 2.5 μM, and 77 nM for RARα, β, and γ, respectively). CD437 is cytotoxic to the acute myeloid leukemia cell line NB4 (EC₅₀ = 0.17 μM), inducing DNA damage by producing DNA double strand breaks. CD437 also induces cell cycle arrest and apoptosis in various other cancer cells including melanoma, breast, non-small lung, and prostate cancer cells through RAR-dependent and -independent signaling pathways. Treatment of mouse embryonic fibroblasts (MEFs) with CD437 early in the reprogramming process significantly increases reprogramming efficiency up to 20-fold.

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