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CD40Ligand/TRAP, human recombinant

A protein primarily expressed on activated T cells and involved in immune functions
Catalog #: 4014
SKU-Size Size Price Qty
4014-10 10 μg
$80.00
4014-50 50 μg
$190.00
4014-1000 1 mg
$1,450.00
More Sizes Get Quote

Product Details

Alternate Name CD40-L, Tumor necrosis factor ligand superfamily member 5, TNF-related activation protein, TRAP, T cell antigen Gp39, CD154 antigen, sCD40, IGM, IMD3, HIGM1, T-BAM, TNFSF5, hCD40L.
Gene Symbol CD40-L
Gene ID 959
Accession # P29965
Source E. coli
Appearance Lyophilized protein
Physical Form Description Lyophilized from a 0.2 μm filtered solution of 20mM PB, 200mM NaCl, 0.1mM EDTA, pH 7.0
Molecular Weight 16.3 kDa
Purity by SDS-PAGE ≥98%
Purity by ≥98%
Endotoxin Level <0.1 ng/μg
Biological Activity Measured by the dose-dependent stimulation of IL-12 & IL-8 induction by PMB cells. ED50 is 5-10 ng/ml.
Reconstitution Instructions Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water. Aliquot the reconstituted solution to minimize freeze-thaw cycles.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer in membrane bound and soluble form, both of which are bioactive. CD40LG is a ligand for CD40; its ligation also initiates signal transduction in CD40LG expressing cells. CD40LG is a differentiation antigen that is expressed on the surface of T-cells. It stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40LG has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL2.


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