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CD40 Antibody

based on 1 citations in multiple journalsCD40 Antibody14.1 4
Catalog #: 3072
SKU-Size Size Price Qty
3072-30T 30 µg
$89.00
3072-100 100 µg
$265.00
More Sizes Get Quote

Product Details

Antibody Target CD40
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide corresponding to residues surrounding amino acids 261 of human CD40
Accession # P25942
Gene ID 958
Appearance Colorless liquid
Concentration 0.2 mg/ml
Formulation 100 µg (0.2 mg/ml) immunoaffinity purified rabbit anti-CD40 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Purification Affinity purified
Species Reactivity Human, mouse, rat, monkey, pig
Application Western blot
Application & Usage Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CD40 is a type I membrane protein found on the surface of B cells and primary carcinomas. It belongs to the TNF-R family. CD40 serves as the receptor for CD40 ligand (CD40L), a cytokine expressed on the cell surface of T cells. CD40 plays a critical role in B cell proliferation, antibody class switching, modulation of apoptosis in the germinal center throμgh interaction with T cells expressing CD40L, and activation of CD4+ T cells. In non-hemopoitic cells such as epidermal basal cells, CD40 ligation serves as the signal for inhibition of cell growth and induction of differentiation. The cytoplasmic domain of CD40 interacts with TRAF6, a TNFR associated factor homolog that mediates signaling from CD40. Ligation of CD40 with its ligand preferentially induces stress-activated protein kinases in B lymphocytes.


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Gao, D., et al. (2005) Gut 54: 70-77.
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