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CD3d Antibody

Polyclonal Antibody to detect CD3d in human and monkey samples.
Catalog #: 6936
$190.00

Product Details

Cat # +Size 6936-50
Size 50 µl
Antibody Target CD3d
Alternate Name T3D; T-cell surface glycoprotein CD3 delta chain; T-cell receptor T3 delta chain; CD3d
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen This CD3d antibody is generated from KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CD3d. The exact sequence is proprietary.
Accession # P04234
Gene ID 915
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation 1 mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification Immunogen Affinity chromatography
Species Reactivity Human, Monkey
Application WB, IF/IC
Positive Control WB: CCRFCEM, Jurkat, HuT78 whole cell lysates, IF/IC: Jurkat cells
Application & Usage WB: 1:500 - 1:1000, IF/IC: 1:100 – 1:500
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

T-cell surface glycoprotein CD3 delta chain, also known as CD3D, is a single-pass type I membrane protein. CD3D, together with CD3-gamma,CD3-epsilon and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. The T cell receptor-CD3 complex is unique in having ten cytoplasmic immunoreceptor tyrosine based activation motifs (ITAMs). Defects in CD3D cause severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK cell-positive (T-/B+/NK+SCID) which is a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels.


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