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CD38 (Cyclase) Inhibitor Screening Kit (Fluorometric)

A plate-based fluorometric assay designed to screen, study and characterize potential inhibitors of CD38 cyclase activity.
Catalog #: K2102
$695.00

Product Details

Cat # +Size K2102-100
Size 100 assays
Kit Summary BioVision’s CD38 (Cyclase) Inhibitor Screening Kit is a plate-based fluorometric assay designed to screen, study and characterize potential inhibitors of CD38 cyclase activity.
Detection Method Fluorescence (Ex/Em = 300/410 nm)
Species Reactivity Mammalian
Applications Screening or characterizing CD38 (Cyclase) inhibitors.
Features & Benefits ● The assay is quick, easy, and sensitive for high-throughput screening of CD38 inhibitors.
● The kit includes a CD38 Inhibitor as a control inhibitor.
Kit Components ● CD38 Assay Buffer
● CD38 Substrate
● CD38, Human Recombinant
● CD38 Inhibitor
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cluster of differentiation 38 (CD38), also known as cyclic ADP ribose hydrolase or ADP-ribosyl cyclase is a multifunctional enzyme that catalyzes the synthesis and hydrolysis of Nicotinamide Adenine Dinucleotide (NAD) to Nicotinamide and ADP-ribose (ADPR). Additionally, CD38 generates second messengers, cyclic ADP-ribose using NAD as the substrate. Due to its role in NAD+ metabolism, the study of CD38 and its functions has been of great importance. It is found on the surface of many immune cells, including plasma B cells, natural killer cells, CD4+, CD8+, etc. Elevated levels of CD38 are associated with aging, obesity, diabetes, heart disease, asthma, inflammation and tumorigenesis etc. BioVision’s CD38 (Cyclase) Inhibitor Screening Kit is a plate-based fluorometric assay designed to screen, study and characterize potential inhibitors of CD38 cyclase activity. The assay utilizes a selective CD38 substrate to generate a fluorescent signal measured at Ex/Em = 300/410 nm. In the presence of potential CD38 cyclase inhibitors, the fluorescent signal is reduced. The assay is quick, easy, and sensitive for high-throughput screening of CD38 inhibitors. Additionally, the kit includes a CD38 Inhibitor as a control inhibitor.


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