Product Details
| Cat # +Size | K2102-100 |
|---|---|
| Size | 100 assays |
| Kit Summary | BioVision’s CD38 (Cyclase) Inhibitor Screening Kit is a plate-based fluorometric assay designed to screen, study and characterize potential inhibitors of CD38 cyclase activity. |
| Detection Method | Fluorescence (Ex/Em = 300/410 nm) |
| Species Reactivity | Mammalian |
| Applications | Screening or characterizing CD38 (Cyclase) inhibitors. |
| Features & Benefits | ● The assay is quick, easy, and sensitive for high-throughput screening of CD38 inhibitors. ● The kit includes a CD38 Inhibitor as a control inhibitor. |
| Kit Components | ● CD38 Assay Buffer ● CD38 Substrate ● CD38, Human Recombinant ● CD38 Inhibitor |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Cluster of differentiation 38 (CD38), also known as cyclic ADP ribose hydrolase or ADP-ribosyl cyclase is a multifunctional enzyme that catalyzes the synthesis and hydrolysis of Nicotinamide Adenine Dinucleotide (NAD) to Nicotinamide and ADP-ribose (ADPR). Additionally, CD38 generates second messengers, cyclic ADP-ribose using NAD as the substrate. Due to its role in NAD+ metabolism, the study of CD38 and its functions has been of great importance. It is found on the surface of many immune cells, including plasma B cells, natural killer cells, CD4+, CD8+, etc. Elevated levels of CD38 are associated with aging, obesity, diabetes, heart disease, asthma, inflammation and tumorigenesis etc. BioVision’s CD38 (Cyclase) Inhibitor Screening Kit is a plate-based fluorometric assay designed to screen, study and characterize potential inhibitors of CD38 cyclase activity. The assay utilizes a selective CD38 substrate to generate a fluorescent signal measured at Ex/Em = 300/410 nm. In the presence of potential CD38 cyclase inhibitors, the fluorescent signal is reduced. The assay is quick, easy, and sensitive for high-throughput screening of CD38 inhibitors. Additionally, the kit includes a CD38 Inhibitor as a control inhibitor.
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