CD28 FITC Monoclonal Antibody (Clone CD28.2)

Mouse monoclonal FITC conjugated antibody to detect CD28 in human samples.
Catalog #: 6957 | abID:

Product Details

Antibody Target CD28
Alternate Name CD28, CD 28, CD-28, CD28 antibody, CD28 monoclonal, CD28 monoclonal Ab, CD28 monoclonal antibody, CD28 mAb, CD 28 mAB, CD 28 monoclonal antibody, CD-28 monoclonal antibody, CD-28 mAB, CD-28 monoclonal antibody, CD28 FITC antibody, CD28 FITC monoclonal, CD28 FITC monoclonal Ab, CD28 FITC monoclonal antibody, CD28 FITC mAb, CD 28 FITC mAB, April-AB-15
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG1, Kappa
Immunogen Human CD28
Accession # P10747
Gene ID 940
Appearance Colorless liquid
Formulation Phosphate-buffered aqueous solution pH 7.2, ≤0.09% Sodium azide, may contain carrier protein/stabilizer.
Purification Affinity chromatography.
Species Reactivity Human
Application Flow cytometry
Positive Control FACS: Human peripheral blood lymphocytes
Application & Usage Flow (Cell Surface): 5 µl/1x10^6 cells, Volume per test: 5 µl (0.5 µg).
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CD28 (Cluster of Differentiation 28) is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. The CD28.2 monoclonal antibody specifically binds with the human 44 kDa homodimeric trans-membrane glycoprotein CD28, expressed on the surface of most mature T lymphocytes, plasma cells, and thymocytes. CD28 is a ligand for B7-1 (CD80) and B7-2 (CD86), a co-stimulator of T lymphocytes, and enhances the interaction between T and B lymphocytes. It has been reported that the T lymphocytes stimulation to produce IL-2 depends on the monoclonal antibody involved, which suggests that the CD28 molecule presents some sub regions with distinct functions. The CD28.2 antibody induces Ca2+ influx in Jurkat T lymphocytes. Other studies have shown that CD28 is involved in the signal transduction.


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