Product Details
| Antibody Target | CD28 |
|---|---|
| Alternate Name | CD28, CD 28, CD-28, CD28 antibody, CD28 monoclonal, CD28 monoclonal Ab, CD28 monoclonal antibody, CD28 mAb, CD 28 mAB, CD 28 monoclonal antibody, CD-28 monoclonal antibody, CD-28 mAB, CD-28 monoclonal antibody, CD28 FITC antibody, CD28 FITC monoclonal, CD28 FITC monoclonal Ab, CD28 FITC monoclonal antibody, CD28 FITC mAb, CD 28 FITC mAB, April-AB-15 |
| Host | Mouse |
| Antibody Type | Monoclonal |
| Isotype | Mouse IgG1, Kappa |
| Immunogen | Human CD28 |
| Accession # | P10747 |
| Gene ID | 940 |
| Appearance | Colorless liquid |
| Formulation | Phosphate-buffered aqueous solution pH 7.2, ≤0.09% Sodium azide, may contain carrier protein/stabilizer. |
| Purification | Affinity chromatography. |
| Species Reactivity | Human |
| Application | Flow cytometry |
| Positive Control | FACS: Human peripheral blood lymphocytes |
| Application & Usage | Flow (Cell Surface): 5 µl/1x10^6 cells, Volume per test: 5 µl (0.5 µg). |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
CD28 (Cluster of Differentiation 28) is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. The CD28.2 monoclonal antibody specifically binds with the human 44 kDa homodimeric trans-membrane glycoprotein CD28, expressed on the surface of most mature T lymphocytes, plasma cells, and thymocytes. CD28 is a ligand for B7-1 (CD80) and B7-2 (CD86), a co-stimulator of T lymphocytes, and enhances the interaction between T and B lymphocytes. It has been reported that the T lymphocytes stimulation to produce IL-2 depends on the monoclonal antibody involved, which suggests that the CD28 molecule presents some sub regions with distinct functions. The CD28.2 antibody induces Ca2+ influx in Jurkat T lymphocytes. Other studies have shown that CD28 is involved in the signal transduction.
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