Anti-CD276 Antibody (6A1)

Monoclonal antibody to detect CD276 in human samples.
Catalog #: A1070 | abID:

Product Details

Cat # +Size A1070-50
Size 50 µl
Antibody Target CD276
Alternate Name CD276 antigen, 4Ig-B7-H3, B7 homolog 3, B7-H3, Costimulatory molecule, CD276, CD276, B7H3
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG1
Immunogen Purified recombinant fragment of human CD276 expressed in E. Coli.
Accession # Q5ZPR3
Gene ID 80381
Appearance Colorless liquid
Formulation Ascitic fluid containing 0.03% sodium azide.
Species Reactivity Human
Application Affinity purified
Positive Control IHC, FC, WB
Application & Usage WB~~1/500 - 1/2000, IHC~~1/200 - 1/1000, FC~~1/200 - 1/400
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Costimulatory B7 molecules (e.g., B7-1, or CD80; MIM 112203) signal through CD28 (MIM 186760) family molecules such as CD28, CTLA4 (MIM 123890), and ICOS (MIM 604558). May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.

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