Product Details
| Cat # +Size | A1074-100 |
|---|---|
| Size | 100 µg |
| Antibody Target | CD27 |
| Alternate Name | CD27 antigen, CD27L receptor, T-cell activation antigen CD27, T14, Tumor necrosis factor receptor superfamily member 7, CD27, CD27, TNFRSF7 |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | KLH conjugated synthetic peptide between 196-225 amino acids from the C-terminal region of human CD27. |
| Accession # | P26842 |
| Gene ID | 939 |
| Appearance | Colorless liquid |
| Formulation | PBS with 0.09% (W/V) sodium azide. |
| Purification | Protein A column, followed by peptide affinity purification. |
| Species Reactivity | Human |
| Application | WB, FC |
| Positive Control | FC |
| Application & Usage | WB~~1:1000FC~~1:10~50 |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
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