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Anti-CD160 Antibody

Polyclonal antibody to detect CD160 in human samples.
Catalog #: A1072
$155.00

Product Details

Cat # +Size A1072-100
Size 100 µl
Antibody Target CD160
Alternate Name CD160 antigen, Natural killer cell receptor BY55, CD160, CD160, BY55
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen KLH conjugated synthetic peptide between 56-82 amino acids from the Central region of human CD160.
Accession # O95971
Gene ID 11126
Appearance Colorless liquid
Formulation PBS with 0.09% (W/V) sodium azide.
Purification Protein A column, followed by peptide affinity purification.
Species Reactivity Human
Application WB
Positive Control WB
Application & Usage WB: 1:1001
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CD160 is a 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+ CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules.


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