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Anti-CD144 (VE-Cadherin) Antibody

Polyclonal antibody to detect endogenous levels of CD144 in human and mouse samples.
Catalog #: A1148
$295.00

Product Details

Cat # +Size A1148-100
Size 100 µl
Antibody Target CDH5
Alternate Name Cadherin-5; 7B4 antigen; Vascular endothelial cadherin; VE-cadherin; CD144
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CD144
Accession # P33151
Gene ID 1003
Appearance Colorless liquid
Formulation In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide
Purification Affinity purified
Species Reactivity Human, Mouse
Application WB
Positive Control WB: HeLa, mouse lung, mouse heart lysates
Application & Usage WB; 1:500 – 1:2000
Handling The antibody solution should be gently mixed before use
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.


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