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CD-14, mouse recombinant

A high affinity receptor for complexes of LPS and LPS binding protein
Catalog #: 4938
$395.00

Product Details

Cat # +Size 4938-10
Size 10 μg
Alternate Name CD14, Cluster of differentiation 14, Human CD14, CD14, h-CD14, rh-CD14, recombinant human CD14, recombinant CD14, CD14, Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein
Gene Symbol CD14
Gene ID 12475
Accession # P10810
Source CHO cells
Appearance Lyophilized protein
Physical Form Description Lyophilized from a concentrated protein solution (1 mg/ml) containing PBS, pH 7.2
Molecular Weight 50.0 kDa
Purity by SDS-PAGE 90-95%
Endotoxin Level <0.1 ng/μg
Biological Activity Inhibits binding of LPS to CD14. Up to 5µg/ml mouse CD14 inhibit binding of FITC-LPS (0.5µg/ml) to mouse CD14+ CHO transfectants
Reconstitution Instructions Reconstitute in 10 µl of ultra-pure distilled water. This solution can then be diluted into other aqueous buffers and stored at –20°C or –70°C for future use.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

CD14 acts as a receptor for endotoxin (LPS), is expressed strongly on monocy¬tes, macrophages and weekly at surface of neutrophiles. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol (GPI) and functions as a high affinity receptor LPS-LBP (lipopolysaccharide binding protein)-complexes. Furthermore CD14 is present in a soluble form in human serum, urine and other body fluids, acts at physiological concentrations as LPS agonist and has at higher concentrations an antagonizing effect in cell activation. The myeloid differentiation antigen CD14 acts as the major receptor for bacterial LPS. The dominant form of the recombinant wild type CD14 is the 50 kDa protein. This is a His-tagged protein.


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