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CCT-251545

A potent wnt signaling inhibitor
Catalog #: B2501

In stock

SKU-Size Size Price Qty
B2501-1 1 mg
$75.00
B2501-5 5 mg
$275.00
More Sizes Get Quote

Product Details

Alternate Name CCT251545; 8-[3-chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one
Appearance Crystalline solid
CAS # 1661839-45-7
Molecular Formula C₂₃H₂₄ClN₅O
Molecular Weight 421.93
Purity ≥98% by HPLC
Solubility >40 mg/ml in DMSO
SMILES CN1C=C(C=N1)C2=CC=C(C=C2)C3=CN=CC(=C3N4CCC5(CCNC5=O)CC4)Cl
InChi InChI=1S/C23H24ClN5O/c1-28-15-18(12-27-28)16-2-4-17(5-3-16)19-13-25-14-20(24)21(19)29-10-7-23(8-11-29)6-9-26-22(23)30/h2-5,12-15H,6-11H2,1H3,(H,26,30)
InChi Key LBFYQISQYCGDDW-UHFFFAOYSA-N
PubChem CID 77050682
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CCT-251545 is a potent Wnt signaling inhibitor (IC₅₀ = 5 nM). It is a selective inhibitor of the human mediator complex-associated protein kinases Cdk8 and Cdk19. Through its effects on Cdk8 and Cdk19, CCT-251545 alters Wnt pathway-regulated gene expression. CCT-251545 demonstrates weak inhibition of tankyrase enzymes (TNKS1 IC50 > 10 μM, TNKS2 IC50 = 15.0 ± 0 μM).


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