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CCT-241736

A potent dual FLT3-Aurora inhibitor
Catalog #: B2370

In stock

SKU-Size Size Price Qty
B2370-5 5 mg
$115.00
B2370-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name CCT241736, 6-chloro-7-[4-[(4-chlorophenyl)methyl]-1-piperazinyl]-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine
Appearance Crystalline solid
CAS # 1402709-93-6
Molecular Formula C₂₂H₂₃Cl₂N₇
Molecular Weight 456.38
Purity ≥98% by HPLC
Solubility >50 mg/ml in DMSO
SMILES CC1=NN(C=C1C2=NC3=NC=C(C(=C3N2)N4CCN(CC4)CC5=CC=C(C=C5)Cl)Cl)C
InChi InChI=1S/C22H23Cl2N7/c1-14-17(13-29(2)28-14)21-26-19-20(18(24)11-25-22(19)27-21)31-9-7-30(8-10-31)12-15-3-5-16(23)6-4-15/h3-6,11,13H,7-10,12H2,1-2H3,(H,25,26,27)
InChi Key AKJBLKUZXRMECW-UHFFFAOYSA-N
PubChem CID 454279
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CCT-241736 is a potent dual FLT3-Aurora inhibitor (IC₅₀ values against FLT3, Aurora A and Aurora B of 0.035, 0.015 and 0.1 μM respectively). CCT241736 inhibits a wide range of FLT3 mutants, including FLT3-ITD, -D835Y, -D835H, -K663Q and -N841I.


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