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CCT-137690

A potent Aurora kinases inhibitor
Catalog #: B1935

In stock

SKU-Size Size Price Qty
B1935-5 5 mg
$125.00
B1935-25 25 mg
$495.00

Product Details

Alternate Name 3-[[4-[6-bromo-2-[4-(4-methylpiperazin-1-yl)phenyl]-1H-imidazo[4,5-b]pyridin-7-yl]piperazin-1-yl]methyl]-5-methyl-1,2-oxazole
Appearance Crystalline solid
CAS # 1095382-05-0
Molecular Formula C₂₆H₃₁BrN₈O
Molecular Weight 551.48
Purity ≥98% by HPLC
Solubility DMSO (~ 7 mg/ml)
SMILES CC1=CC(=NO1)CN2CCN(CC2)C3=C4C(=NC=C3Br)N=C(N4)C5=CC=C(C=C5)N6CCN(CC6)C
InChi InChI=1S/C26H31BrN8O/c1-18-15-20(31-36-18)17-33-9-13-35(14-10-33)24-22(27)16-28-26-23(24)29-25(30-26)19-3-5-21(6-4-19)34-11-7-32(2)8-12-34/h3-6,15-16H,7-14,17H2,1-2H3,(H,28,29,30)
InChi Key GFLQCBTXTRCREJ-UHFFFAOYSA-N
PubChem CID 25154041
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CCT137690 is a highly selective and orally bioavailable inhibitor of Aurora A, Aurora B and Aurora C with IC₅₀ of 15 nM, 25 nM and 19 nM, respectively. Displays anti-tumor activities both in vitro and in vivo.


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