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CCT-129202

A potent, ATP-competitive inhibitor of Aurora kinases
Catalog #: B1934

In stock

SKU-Size Size Price Qty
B1934-1 1 mg
$85.00
B1934-5 5 mg
$335.00

Product Details

Appearance Crystalline solid
CAS # 942947-93-5
Molecular Formula C₂₃H₂₅ClN₈OS
Molecular Weight 497.02
Purity ≥98% by HPLC
Solubility DMSO (~ 3 mg/ml)
SMILES CN(C)C1=CC=C(C=C1)C2=NC3=NC=C(C(=C3N2)N4CCN(CC4)CC(=O)NC5=NC=CS5)Cl
InChi InChI=1S/C23H25ClN8OS/c1-30(2)16-5-3-15(4-6-16)21-28-19-20(17(24)13-26-22(19)29-21)32-10-8-31(9-11-32)14-18(33)27-23-25-7-12-34-23/h3-7,12-13H,8-11,14H2,1-2H3,(H,25,27,33)(H,26,28,29)
InChi Key QYKHWEFPFAGNEV-UHFFFAOYSA-N
PubChem CID 16202152
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CCT-129202 is a potent, ATP-competitive inhibitor of Aurora kinases with IC₅₀ values of 42 nM, 198 nM and 227 nM for Aurora A, B and C, respectively. CCT-129202 displays high selectivity for the Aurora kinases over a panel of other kinases tested and inhibits proliferation in multiple cultured human tumor cell lines. 


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