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CCL4 Antibody (Center)

Polyclonal Antibody to detect CCL4 in human and mouse samples.
Catalog #: 6731

In stock

$245.00

Product Details

Cat # +Size 6731-100
Size 100 μl
Antibody Target CCL4
Alternate Name CCL4; LAG1; MIP1B; SCYA4; C-C motif chemokine 4; G-26 T-lymphocyte-secreted protein; HC21; Lymphocyte activation gene 1 protein; MIP-1-beta(1-69); Macrophage inflammatory protein 1-beta; PAT 744; Protein H400; SIS-gamma; Small-inducible cytokine A4; T-cell activation protein 2.
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen This CCL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-48 amino acids from the Central region of human CCL4.
Accession # P13236
Gene ID 6351
Appearance Colorless liquid
Formulation 100 µl of antibody in PBS with 0.09% (W/V) sodium azide
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Species Reactivity Human and mouse
Application Western blot, IHC
Positive Control Western blot: Mouse Bladder tissue lysate, IHC: human prostate carcinoma
Application & Usage Western blot: ~1:1000, IHC: ~1:10–1:50.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CCL4 is a member of the CC- subfamily of chemokines and is most closely related to CCL3, or MIP-1 alpha. These proteins play critical roles in the recruitment of leukocytes to the site of inflammation. In addition to its chemotactic functions, CCL4 induces the release of proinflammatory cytokine, mast cells degranulation, and NK cell activation. CCL4 signaling is mediated by the G protein-coupled receptors CCR1, CCR4, and CCR5, which are shared with CCL3 and CCL5 (RANTES). CCR5 is the primary co-receptor for HIV entry, which the virus binds through the gp120 envelope protein. All CCR5 ligands demonstrate potent inhibition of virus entry into the cell, both through steric hindrance of gp120-CCR5 interaction, and ligand-mediated receptor internalization.


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