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CCL24 (Human) ELISA Kit

A highly sensitive sandwich ELISA kit for the quantitative measurement of CCL24

WARNING: This product can expose you to chemicals including Sulfuric acid and TMB, which are known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.
Catalog #: E5119
$750.00

Product Details

Cat # +Size E5119-100
Size 96 assays
Detection Method Absorbance is measured at 450 nm
Species Reactivity Human
Applications The ELISA kit is used for the quantitative detection of CCL24 in serum, plasma, tissue homogenates and other biological fluids
Features & Benefits ● Assay Precision; Intra-Assay CV < 8% and Inter-Assay < 10%
● Sensitivity: 9.375 pg/ml
● Detection range: 15.625-1000 pg/ml
● Recovery Rate: 85-99% for serum, 86-94% for EDTA plasma and 93-103% for heparin plasma
● Highly sensitive and specific
Kit Components ● ELISA Microplate
● Wash Buffer (25X)
● Plate Sealers
● Lyophilized Standard (1000 pg)
● Sample/Standard Dilution Buffer
● Biotin-labeled Antibody (Concentrated)
● Antibody Dilution Buffer
● HRP-Streptavidin Conjugate (SABC)
● SABC Dilution Buffer
● TMB Substrate
● Stop Solution
Storage Conditions 4ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CCL24 is a small cytokine belonging to the CC chemokine family which is also known as myeloid progenitor inhibitory factor 2 (MPIF-2) or eosinophil chemotactic protein 2 (eotaxin-2). CCL24 interacts with chemokine receptor CCR3 to induce chemotaxis in eosinophils. It is chemotactic for resting T-lymphocytes, and eosinophils and has a lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Elevated levels of CCL24 have been seen in patients with aspirin-exacerbated respiratory disease, such as asthma. CCL24 plays an important role in pathological processes of skin and lung inflammation and fibrosis. Inhibition of CCL24 by CM-101 mAb can be potentially beneficial for therapeutic use in systemic sclerosis patients. CCL24 contribute to the biology of cancer by M2 macrophage polarization, angiogenesis, invasion and migration, and recruitment of eosinophils. CCL24 can be used as a potential biomarker in several cancers including colon cancer, non-small cell cancer, and nasopharyngeal carcinoma as the plasma level of CCL24 is increased. BioVision’s CCL24 (Human) ELISA Kit is used for the quantitative detection of CCL24 in serum, plasma, tissue homogenates and other biological fluids. It is based on the principle of sandwich ELISA. The capture antibody is pre-coated on 96-well plates. The standards, test samples and biotin conjugated detection antibody are added to the wells subsequently, and washed with wash buffer. HRP-Streptavidin is added and unbound conjugates are washed away with wash buffer. The HRP enzymatic reaction is detected using TMB-substrate. Finally, an acidic stop solution terminates the enzymatic reaction. The color developed is directly proportional to the amount of CCL24 in the sample.


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