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A potent ERK1/2 inhibitor
Catalog #: B2419
SKU-Size Size Price Qty
B2419-1 1 mg
B2419-5 5 mg
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Product Details

Alternate Name CC90003, N-(2-((2-((2-methoxy-5-methylpyridin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)-5-methylphenyl)acrylamide
Appearance Crystalline solid
CAS # 1621999-82-3
Molecular Formula C₂₂H₂₁F₃N₆O₂
Molecular Weight 458.44
Purity ≥98% by HPLC
Solubility >50 mg/ml in DMSO
InChi InChI=1S/C22H21F3N6O2/c1-5-18(32)28-17-8-12(2)6-7-15(17)29-20-14(22(23,24)25)11-27-21(31-20)30-16-9-19(33-4)26-10-13(16)3/h5-11H,1H2,2-4H3,(H,28,32)(H2,26,27,29,30,31)
PubChem CID 90331177
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


CC-90003 is a potent extracellular signal-regulated kinases (ERK1/2) inhibitor. CC-90003 inhibits ERK activity, and prevents the activation of ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival.

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