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CC-115

A dual DNA-PK and mTOR inhibitor
Catalog #: B2499
SKU-Size Size Price Qty
B2499-5 5 mg
$135.00
B2499-25 25 mg
$535.00
More Sizes Get Quote

Product Details

Alternate Name 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-5-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one; CC115
Appearance Crystalline solid
CAS # 1228013-15-7
Molecular Formula C₁₆H₁₆N₈O
Molecular Weight 336.35
Purity ≥98% by HPLC
Solubility ~10 mg/ml in DMSO
SMILES CCN1C(=O)CNC2=NC=C(N=C21)C3=C(N=C(C=C3)C4=NC=NN4)C
InChi InChI=1S/C16H16N8O/c1-3-24-13(25)7-18-15-16(24)22-12(6-17-15)10-4-5-11(21-9(10)2)14-19-8-20-23-14/h4-6,8H,3,7H2,1-2H3,(H,17,18)(H,19,20,23)
InChi Key GMYLVKUGJMYTFB-UHFFFAOYSA-N
PubChem CID 58298318
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CC-115 is a potent dual inhibitor of mTOR and DNA-PK (IC₅₀s = 22 and 15 nM, respectively). CC-115 reduces PC3 cancer cell growth in vitro (IC₅₀ = 138 nM) and displays effective reduction of murine PC3 tumor xenografts.


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