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Facilitates chromatin transcription (FACT) Inhibitor
Catalog #: B2036

In stock

SKU-Size Size Price Qty
B2036-5 5 mg
B2036-25 25 mg
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Product Details

Alternate Name 1,1'-[9-[2-[(1-methylethyl)amino]ethyl]-9H-carbazole-3,6-diyl]-bis-ethanone; Curaxin 137
Appearance Crystalline solid
CAS # 1197996-80-7
Molecular Formula C₂₁H₂₄N₂O₂
Molecular Weight 336.4
Purity ≥98% by HPLC
Solubility DMSO (~5 mg/ml)
InChi InChI=1S/C21H24N2O2/c1-13(2)22-9-10-23-20-7-5-16(14(3)24)11-18(20)19-12-17(15(4)25)6-8-21(19)23/h5-8,11-13,22H,9-10H2,1-4H3
PubChem CID 44519124
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


CBL0137 is a metabolically stable curaxin that activates p53 (EC₅₀ = 0.37 μM) and inhibits NF-κB (EC₅₀ = 0.47 μM). It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-κB and promoting cancer cell death. CBL0137 has broad anticancer activity in mice when administered orally, eradicates drug-resistant cancer stem cells, and potentiates efficacy of gemcitabine (Cat. No.1759 in preclinical models of pancreatic cancer.

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