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CBHA

A potent HDAC1 and HDAC3 inhibitor
Catalog #: 2284

In stock

SKU-Size Size Price Qty
2284-5 5 mg
$105.00
2284-10 10 mg
$195.00
More Sizes Get Quote

Product Details

Alternate Name N-​hydroxy-​3-​[3-​(hydroxyamino)-​3-​oxo-​1-​propen-​1-​yl]-​benzamide; m-Carboxycinnamic Acid bis-Hydroxamide
Peptide Sequence No
Appearance Crystalline solid
CAS # 174664-65-4
Molecular Formula C₁₀H₁₀N₂O₄
Molecular Weight 222.2
Purity ≥98%
Solubility DMSO
SMILES C1=CC(=CC(=C1)C(=O)NO)C=CC(=O)NO
InChi InChI=1S/C10H10N2O4/c13-9(11-15)5-4-7-2-1-3-8(6-7)10(14)12-16/h1-6,15-16H,(H,11,13)(H,12,14)/b5-4+
InChi Key OYKBQNOPCSXWBL-SNAWJCMRSA-N
PubChem CID 5353484
MDL Number MFCD03453553
Handling Protect from light and moisture
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A potent histone deacetylase (HDAC) inhibitor (ID₅₀ values of 0.01 and 0.07 μM in vitro for HDAC1 and HDAC3, respectively). CBHA also induces apoptosis in nine different neuroblastoma cell lines in culture (0.5-4.0 μM) and completely suppresses neuroblastoma tumor growth in SCID mice at 200 mg/ kg.


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