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CBFb polyclonal antibody

Polyclonal Antibody to detect CBFb in human samples.
Catalog #: 6835
$245.00

Product Details

Cat # +Size 6835-50
Size 50 μl
Antibody Target CBFb
Alternate Name PEBP2B, CBF-beta, PEA2-beta, PEB2-beta
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Polyclonal antibody raised in rabbit against human CBFb (core-binding factor, beta subunit) using two KLH conjugated synthetic peptides containing sequences from the central region of the protein.
Accession # Q13951
Gene ID 865
Appearance Colorless liquid
Formulation In PBS with 0.05% (W/V) sodium azide.
Purification Whole Anti-Sera
Species Reactivity Human.
Application ELISA, ChIP.
Positive Control ELISA: Peptides, ChIP: SKNO-1 cells.
Application & Usage ChIP: 4 µl/ChIP, ELISA: 1:500.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CBFb represents the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family. These transcription factors regulate a host of genes specific to hematopoiesis (e.g. RUNX1) and osteogenesis (e.g. RUNX2). The beta subunit is the regulatory subunit which allosterically enhances the activity of the DNA binding alpha subunit as the complex binds to the core site of various enhancers and promoters. CBFb can be involved in a chromosomal rearrangement of chromosome 16 (inv(16)(p13q22)) which produces a fusion protein consisting of the N terminus of CBFb and the C-terminal portion of MYH11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype.


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