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Product Details
| Alternate Name | HDAC6 Inhibitor, tert-butyl N-[4-[3-[[7-(hydroxyamino)-7-oxoheptyl]carbamoyl]-1,2-oxazol-5-yl]phenyl]carbamate, tert-butyl N-[4-[3-[[7-(hydroxyamino)-7-oxoheptyl]carbamoyl]-1,2-oxazol-5-yl]phenyl]carbamate, {4-[3-(6-Hydroxycarbamoylhexylcarbamoyl)isoxazol-5-yl]phenyl}carbamic acid tert-butyl ester, Histone Deacetylase Inhibitor VIII |
|---|---|
| Appearance | Crystalline solid |
| CAS # | 1045792-66-2 |
| Molecular Formula | C₂₂H₃₀N₄O₆ |
| Molecular Weight | 446.50 |
| Purity | >98% |
| Solubility | ~15 mg/ml in DMSO |
| SMILES | CC(C)(C)OC(=O)NC1=CC=C(C=C1)C2=CC(=NO2)C(=O)NCCCCCCC(=O)NO |
| InChi | InChI=1S/C22H30N4O6/c1-22(2,3)31-21(29)24-16-11-9-15(10-12-16)18-14-17(26-32-18)20(28)23-13-7-5-4-6-8-19(27)25-30/h9-12,14,30H,4-8,13H2,1-3H3,(H,23,28)(H,24,29)(H,25,27) |
| InChi Key | WWGBHDIHIVGYLZ-UHFFFAOYSA-N |
| PubChem CID | 24951314 |
| MDL Number | MFCD17010286 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20ºC |
| Shipping Conditions | RT |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
CAY10603 is a selective inhibitor of Histone deacetylase 6 (HDAC6). The IC₅₀ for inhibition of HDAC6 is 2 pM, in vitro. CAY10603 inhibited growth of various pancreatic cell lines with IC₅₀ values ranging from 0.1 μM to 1 μM. It induced apoptosis and inhibited the proliferation of lung adenocarcinoma cells.
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