A selective inhibitor of HDAC6
Catalog #: B2819 | abID:

Product Details

Alternate Name HDAC6 Inhibitor, tert-butyl N-[4-[3-[[7-(hydroxyamino)-7-oxoheptyl]carbamoyl]-1,2-oxazol-5-yl]phenyl]carbamate, tert-butyl N-[4-[3-[[7-(hydroxyamino)-7-oxoheptyl]carbamoyl]-1,2-oxazol-5-yl]phenyl]carbamate, {4-[3-(6-Hydroxycarbamoylhexylcarbamoyl)isoxazol-5-yl]phenyl}carbamic acid tert-butyl ester, Histone Deacetylase Inhibitor VIII
Appearance Crystalline solid
CAS # 1045792-66-2
Molecular Formula C₂₂H₃₀N₄O₆
Molecular Weight 446.50
Purity >98%
Solubility ~15 mg/ml in DMSO
InChi InChI=1S/C22H30N4O6/c1-22(2,3)31-21(29)24-16-11-9-15(10-12-16)18-14-17(26-32-18)20(28)23-13-7-5-4-6-8-19(27)25-30/h9-12,14,30H,4-8,13H2,1-3H3,(H,23,28)(H,24,29)(H,25,27)
PubChem CID 24951314
MDL Number MFCD17010286
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


CAY10603 is a selective inhibitor of Histone deacetylase 6 (HDAC6). The IC₅₀ for inhibition of HDAC6 is 2 pM, in vitro. CAY10603 inhibited growth of various pancreatic cell lines with IC₅₀ values ranging from 0.1 μM to 1 μM. It induced apoptosis and inhibited the proliferation of lung adenocarcinoma cells.

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