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CAY10602

An activator of SIRT1
Catalog #: B2914
SKU-Size Size Price Qty
B2914-5 5 mg
$115.00
B2914-25 25 mg
$460.00
More Sizes Get Quote

Product Details

Alternate Name 3-(benzenesulfonyl)-1-(4-fluorophenyl)pyrrolo[3,2-b]quinoxalin-2-amine; 1-(4-Fluorophenyl)-3-(phenylsulfonyl)-1H-pyrrolo(2,3-B)quinoxalin-2-amine; SIRT1 Activator II
Appearance A crystalline solid
CAS # 374922-43-7
Molecular Formula C₂₂H₁₅FN₄O₂S
Molecular Weight 418.4
Purity ≥95%
Solubility ~20 mg/ml in DMSO and DMF
SMILES C1=CC=C(C=C1)S(=O)(=O)C2=C(N(C3=NC4=CC=CC=C4N=C23)C5=CC=C(C=C5)F)N
InChi InChI=1S/C22H15FN4O2S/c23-14-10-12-15(13-11-14)27-21(24)20(30(28,29)16-6-2-1-3-7-16)19-22(27)26-18-9-5-4-8-17(18)25-19/h1-13H,24H2
InChi Key CSFVFDHRYKBBPD-UHFFFAOYSA-N
PubChem CID 1915791
MDL Number MFCD02236691
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

CAY10602 is an activator of SIRT1. The sirtuins (SIRTs) are NAD+-dependent histone deacetylases. SIRT1 alters gene expression by deacetylating transcription factors such as NF-κB, p53, and FOXO. CAY10602 suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide in THP-1 cells at 20 μM and 60 μM. It is more potent as a suppressor of TNF-α release than resveratrol.


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