Product Details
| Alternate Name | 5-(5,6-dimethoxybenzimidazol-1-yl)-3-[(4-methylsulfonylphenyl)methoxy]thiophene-2-carboxamide; BMCL191018 Compound 39; BDBM27444 |
|---|---|
| Appearance | A crystalline solid |
| CAS # | 916985-21-2 |
| Molecular Formula | C₂₂H₂₁N₃O₆S₂ |
| Molecular Weight | 487.6 |
| Purity | ≥95% |
| Solubility | ~10 mg/ml in DMSO ~1 mg/ml in DMF |
| SMILES | COC1=C(C=C2C(=C1)N=CN2C3=CC(=C(S3)C(=O)N)OCC4=CC=C(C=C4)S(=O)(=O)C)OC |
| InChi | InChI=1S/C22H21N3O6S2/c1-29-17-8-15-16(9-18(17)30-2)25(12-24-15)20-10-19(21(32-20)22(23)26)31-11-13-4-6-14(7-5-13)33(3,27)28/h4-10,12H,11H2,1-3H3,(H2,23,26 |
| InChi Key | YYZTVTZCYVZGRB-UHFFFAOYSA-N |
| PubChem CID | 25190912 |
| MDL Number | MFCD10567699 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20ºC |
| Shipping Conditions | RT |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
CAY10575 is an inhibitor of IKK-ε. IKK-ε is a homolog of IKK-α and IKK-β which can activate NF-κB. NF-κB is activated upon degradation of IκB following IKK-α and IKK-β phosphorylation. CAY10575 is a benzimidazole analog that inhibits IKK-ε with an IC₅₀ value of ~15.8 µM.
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