An inhibitor of IKK-ε
Catalog #: B2912 | abID:

Product Details

Alternate Name 5-(5,6-dimethoxybenzimidazol-1-yl)-3-[(4-methylsulfonylphenyl)methoxy]thiophene-2-carboxamide; BMCL191018 Compound 39; BDBM27444
Appearance A crystalline solid
CAS # 916985-21-2
Molecular Formula C₂₂H₂₁N₃O₆S₂
Molecular Weight 487.6
Purity ≥95%
Solubility ~10 mg/ml in DMSO
~1 mg/ml in DMF
InChi InChI=1S/C22H21N3O6S2/c1-29-17-8-15-16(9-18(17)30-2)25(12-24-15)20-10-19(21(32-20)22(23)26)31-11-13-4-6-14(7-5-13)33(3,27)28/h4-10,12H,11H2,1-3H3,(H2,23,26
PubChem CID 25190912
MDL Number MFCD10567699
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


CAY10575 is an inhibitor of IKK-ε. IKK-ε is a homolog of IKK-α and IKK-β which can activate NF-κB. NF-κB is activated upon degradation of IκB following IKK-α and IKK-β phosphorylation. CAY10575 is a benzimidazole analog that inhibits IKK-ε with an IC₅₀ value of ~15.8 µM.

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