Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]


A potent inhibitor of PI3K-γ
Catalog #: B2962
SKU-Size Size Price Qty
B2962-5 5 mg
B2962-25 25 mg
More Sizes Get Quote

Product Details

Alternate Name (5E)-5-{[5-(4-fluorophenyl)furan-2-yl]methylidene}-1,3-thiazolidine-2,4-dione; 5-[[5-(4-fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione
Appearance Solid
CAS # 1218777-13-9, 328960-84-5
Molecular Formula C₁₄H₈FNO₃S
Molecular Weight 289.28
Purity 99.8%
Solubility ~20 mg/ml in DMSO and DMF
InChi InChI=1S/C14H8FNO3S/c15-9-3-1-8(2-4-9)11-6-5-10(19-11)7-12-13(17)16-14(18)20-12/h1-7H,(H,16,17,18)/b12-7+
PubChem CID 1204893
MDL Number MFCD00640727
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


CAY10505 is a potent inhibitor of phosphoinositide 3-kinase (PI3K), selectively inhibiting the γ isoform with an IC₅₀ of 30 nM. It inhibits the α, β, and δ isoforms of PI3K with IC₅₀ values of 0.94, 20, and 20 μM, respectively. It significantly inhibits the unrelated casein kinase 2 (CK2) with an IC₅₀ of 20 nM. It also inhibits the phosphorylation of the PI3K substrate PKB/Akt in mouse macrophages with an IC₅₀ of 228 nM. It improves hypertension-associated vascular endothelial dysfunction in rats.

Why buy BioVision Products?
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.