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CAY10505

A potent inhibitor of PI3K-γ
Catalog #: B2962
SKU-Size Size Price Qty
B2962-5 5 mg
$65.00
B2962-25 25 mg
$260.00
More Sizes Get Quote

Product Details

Alternate Name (5E)-5-{[5-(4-fluorophenyl)furan-2-yl]methylidene}-1,3-thiazolidine-2,4-dione; 5-[[5-(4-fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione
Appearance Solid
CAS # 1218777-13-9, 328960-84-5
Molecular Formula C₁₄H₈FNO₃S
Molecular Weight 289.28
Purity 99.8%
Solubility ~20 mg/ml in DMSO and DMF
SMILES C1=CC(=CC=C1C2=CC=C(O2)C=C3C(=O)NC(=O)S3)F
InChi InChI=1S/C14H8FNO3S/c15-9-3-1-8(2-4-9)11-6-5-10(19-11)7-12-13(17)16-14(18)20-12/h1-7H,(H,16,17,18)/b12-7+
InChi Key UFBTYTGRUBUUIL-KPKJPENVSA-N
PubChem CID 1204893
MDL Number MFCD00640727
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

CAY10505 is a potent inhibitor of phosphoinositide 3-kinase (PI3K), selectively inhibiting the γ isoform with an IC₅₀ of 30 nM. It inhibits the α, β, and δ isoforms of PI3K with IC₅₀ values of 0.94, 20, and 20 μM, respectively. It significantly inhibits the unrelated casein kinase 2 (CK2) with an IC₅₀ of 20 nM. It also inhibits the phosphorylation of the PI3K substrate PKB/Akt in mouse macrophages with an IC₅₀ of 228 nM. It improves hypertension-associated vascular endothelial dysfunction in rats.


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