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Cathepsin L Antibody

based on 3 citations in multiple journalsCathepsin L Antibody34.1 4
Catalog #: 3192
SKU-Size Size Price Qty
3192-30T 30 µg
$89.00
3192-100 100 µg
$255.00
More Sizes Get Quote

Product Details

Antibody Target Cathepsin L
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide surrounding amino acid 223 of human Cathepsin L
Accession # P07711
Gene ID 1514
Appearance Colorless liquid
Concentration 0.2 mg/ml
Formulation 100 µg (0.2 mg/ml) affinity purified rabbit anti-cathepsin L polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.1% BSA, 0.01% thimerosal.
Purification Affinity purified
Species Reactivity Human
Application Western blot, Immunohistochemistry
Positive Control Western Blot: Jurkat cell lysate. IHC: Kidney tissue
Application & Usage Western blotting (0.5-4 µg/ml), and Immunohistochemistry (5 µg/ml). However, the optimal conditions should be determined individually. Jurkat cell lysate (Cat.# 2401-100) can be used as a positive control. Detects both the proenzyme and the mature form of
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cathepsin L is a normal lysosomal cysteine endoproteases that is expressed in all cells. The latent 39 kDa pro-Cathepsin L must be processed by cleavage of the 96 amino acid pro-peptide, to generate the active two-chain form made up of 21 and 5 kDa subunits. Mature Cathepsin L is normally localized in the lysosomes where it plays a major role in intracellular protein catabolism. The fact that Cathepsin L is also capable of degrading extracellular matrix proteins sμggests that it may play a role in invasion and metastasis and could be a useful prognostic indicator for cancer.


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Yoshihara et al., The response of apoptotic and proteolytic systems to repeated heat stress in atrophied rat skeletal muscle.  PHY2, Oct 2015; 3: e12597.
Song, G. et al. Cathepsin B, Cathepsin L, and Cystatin C in the Porcine Uterus and Placenta: Potential Roles in Endometrial/Placental Remodeling and in Fluid-Phase Transport of Proteins Secreted by Uterine Epithelia Across Placental Areolae. Biol. Reprod. 2010 82: 854-864.
Song, G., et al. (2005) Endocrinology 146: 4825-4833.
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