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Cathepsin L (Active), Human Liver

Plays a major role in intracellular protein catabolism
Catalog #: 7539
$365.00

Product Details

Cat # +Size 7539-25
Size 25 µg
Alternate Name Cathepsin L1; Major Excreted Protein; CTSL; CTSL1
Gene ID 1514
Accession # P07711
Source Human liver
Appearance Sterile Filtered colorless solution
Physical Form Description Frozen
Molecular Weight 25 to 29 kDa
Formulation 20 mM malonate, pH 5.5, 1 mM EDTA, 400 mM NaCl
Specific Activity Greater than 1 unit per mg of protein, where one unit is defined as the amount of enzyme needed to hydrolyze one micromole of Z-Phe-Arg-AFC per minute at 25 C using 400 mM sodium acetate, pH 5.5. with 4 mM EDTA and 8 mM DTT as the activation buffer in the
Handling Centrifuge the vial prior to opening.
Storage Conditions -70 °C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not For Use in Humans.

Details

Cathepsin L is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Substrates for Cathepsin L include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. Cathepsin L has been implicated in myofibril necrosis in some muscle diseases, and in the renal tubular response to proteinuira. Levels of Cathepsin L is a strong predictor of relapse and survival following primary breast tumor treatment. Recently, Cathepsin L has been shown to cleave the S1 subunit of the SARS-CoV-2 spike protein, which allows viral intry into the cell.


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