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Cathepsin K Antibody

based on 2 citations in multiple journalsCathepsin K Antibody24.1 4
Catalog #: 3588
SKU-Size Size Price Qty
3588-30T 30 µg
$89.00
3588-100 100 µg
$310.00
More Sizes Get Quote

Product Details

Antibody Target Cathepsin K
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide surrounding amino acid 321 of rat cathepsin K
Accession # NP_113748
Gene ID 29175
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 0.5mg/ml in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.03% proclin.
Purification Affinity purified
Species Reactivity Human, mouse, rat, chicken, rabbit, pig
Application Western blot, Immunoprecipitation, Immunohistochemistry
Application & Usage Western blotting (0.5-4 µg/ml), immunoprecipitation, and Immunohistochemistry. However, the optimal conditions should be determined individually. The antibody detects proform (43 kDa) and the mature form (29 kDa) of cathepsin K.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cathepsin family of proteases contains several diverse classes of enzymes. The cysteine protease class comprises cathepsin B, H, K, L, O, and S. The aspartyl protease class contains cathepsin D and E. Cathepsin G belongs to the serine protease class. Cathepsins are involved in various cellular events such as peptide biosynthesis, protein degradation, and apoptosis. Cathepsin K expression is highest in bone, cartilage, and skeletal muscle.


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Christian Sina et. al., Extracellular cathepsin K exerts antimicrobial activity and is protective against chronic intestinal inflammation in mice. Gut, Apr 2013; 62: 520 - 530.
López-Guisa , J. et al., Mannose Receptor 2 Attenuates Renal Fibrosis, J. Am. Soc. Nephrol., Feb 2012; 23: 236 - 251.
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