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Cathepsin K, Active, human recombinant

Predominant proteinase responsible for the resorption of the bone matrix.
Catalog #: 7600
SKU-Size Size Price Qty
7600-5 5 μg
$300.00
7600-50 50 μg
$1,950.00
More Sizes Get Quote

Product Details

Alternate Name CTSK, CTSO, CTSO3
Gene Symbol CTSK
Gene ID 1513
Accession # P43235
Source E. coli
Appearance Liquid
Physical Form Description 0.5 mg/ml solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0) with 50% glycerol.
Molecular Weight 23.5 kDa (115-329 aa)
Purity by SDS-PAGE ≥90%
Biological Activity The specific activity is >5000 mU/mg (1U = 1 µmole/min/mg) as measured by Cathepsin K Activity Assay Kit (Catalog #K141-100)
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

Cathepsin K, a member of the papain cysteine proteinase family is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a role in bone remodeling and resorption in osteoporosis, osteolytic bone metastasis and rheumatoid arthritis (Bromme and Okamoto, 1995; Drake, F. et al 1996; Bossard et al, 1996).


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