Product Details
| abID | ab285940 |
|---|---|
| Alternate Name | CTSK, CTSO, CTSO3 |
| Gene Symbol | CTSK |
| Gene ID | 1513 |
| Accession # | P43235 |
| Source | E. coli |
| Appearance | Liquid |
| Physical Form Description | 0.5 mg/ml solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0) with 50% glycerol. |
| Molecular Weight | 23.5 kDa (115-329 aa) |
| Purity by SDS-PAGE | ≥90% |
| Biological Activity | The specific activity is >5000 mU/mg (1U = 1 μmole/min) as measured by Cathepsin K Activity Assay Kit (Catalog #K141-100) |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -80°C |
| Shipping Conditions | Dry Ice |
| USAGE | For Research Use Only! Not to be used in humans |
Details
Cathepsin K, a member of the papain cysteine proteinase family is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a role in bone remodeling and resorption in osteoporosis, osteolytic bone metastasis and rheumatoid arthritis (Bromme and Okamoto, 1995; Drake, F. et al 1996; Bossard et al, 1996).
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