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Cathepsin B Antibody

based on 2 citations in multiple journalsCathepsin B Antibody24.1 4
Catalog #: 3190
SKU-Size Size Price Qty
3190-30T 30 µg
$89.00
3190-100 100 µg
$265.00
More Sizes Get Quote

Product Details

Antibody Target Cathepsin B
Alternate Name CTSB, CPSB, APPS, EC 3.4.22.1
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide surrounding amino acid 322 of human cathepsins B
Accession # P07858
Gene ID 1508
Appearance Colorless liquid
Concentration 0.2 mg/ml
Formulation 30 µg (0.2 mg/ml) affinity purified rabbit anti-cathepsin B polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Purification Affinity purified
Species Reactivity Human
Application Western blot, Immunohistochemistry, Flow cytometry
Application & Usage Western blotting (0.5-4 µg/ml) amd in Immunohistochemistry (10-20 µg/ml). However, the optimal conditions should be determined individually. The purified antibody detects both the proform (37-43 kDa) and the mature form (25 kDa) of cathepsin B. It reacts
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cathepsin B is a normal lysosomal cysteine proteinase that is expressed in all cells. It is synthesized as an inactive 43 kDa pro-enzyme which, by removal of a 62 amino acid propeptide, is activated to the single-chain form of 31 kDa or the two-chain form (25 and 5 kDa subunits). Matured cathepsin B is normally localized in the lysosomes where it functions in protein turnover. Cathepsin B is also shown capable of degrading extracellular matrix proteins. Elevated levels of cathepsin B correlate with malignancy sμggesting that this enzyme may be a useful prognostic marker for several types of human cancers.


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Balce et al., gammaInterferon-inducible Lysosomal Thiol Reductase (GILT) Maintains Phagosomal Proteolysis in Alternatively Activated Macrophages. J. Biol. Chem.,Nov 2014; 289: 31891 - 31904.
Rybicka JM NADPH oxidase activity controls phagosomal proteolysis in macrophages through modulation of the lumenal purpleox environment of phagosomes.Balce DR, Khan MF, Krohn RM, Yates RM. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10496-501. Epub 2010 May 24.
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